Both nanomaterial geometries can be employed as prospective contrast agents however, at identical concentration, NPs exhibited 4-fold higher cytotoxicity to L929 fibroblasts as compared to NEs, confirming the effect of nanomaterial geometry on cell fate. In contrast, due to the geometric difference, NEs can be optically excited to generate hyperthermia upon photostimulation and elevate the medium temperature to 45 ☌. Our results show that owing to superparamagnetism, NPs can generate hyperthermia upon magnetic field stimulation. To elucidate this and to extend the application in cancer theranostics, we have engineered core–shell cobalt– gold nanoparticles with spherical NPs) and elliptical morphology NEs). However, little is known about the effect of nanomaterial geometry on cell behavior. N2 - The interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior and ample evidence links cell intercommunication to nanomaterial size. T1 - Assessing suitability of core/shell nanoparticle geometry for improved theranostics in colon carcinomaįunding: The authors are grateful for the financial supports of this research by the Ministry of Science and Technology of Taiwan (MOST 108-2628-E-027-003-MY3), the National Taipei University of Technology-Mackay Memorial Hospital Joint Research Program (NTUT-MMH-108-08, NTUT-MMH-109-04). The geometry-based perturbation of cell fate can have a profound impact on our understanding of interactions at nano-bio interface which can be exploited for engineering materials with optimized geometries for superior theranostic applications.", Furthermore, photostimulation-generated hyperthermia prompted detachment of anti-cancer drug, Methotrexate (MTX), from NEs-MTX complex and which triggered 90% decrease in SW620 colon carcinoma cell viability, confirming their application in cancer theranostics.
The geometry-based perturbation of cell fate can have a profound impact on our understanding of interactions at nano-bio interface which can be exploited for engineering materials with optimized geometries for superior theranostic applications.Ībstract = "The interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior and ample evidence links cell intercommunication to nanomaterial size.
The interactions between cells and nanomaterials at the nanoscale play a pivotal role in controlling cellular behavior and ample evidence links cell intercommunication to nanomaterial size.
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